한빛사 논문
Choon-Soo Lee, PhD* Hyun-Jai Cho, MD, PhD* Jin-Woo Lee, MSc Jaewon Lee, BSc Yoo-Wook Kwon, PhD Taekwon Son, PhD Hanseul Park, MSc Jongpil Kim, PhD Hyo-Soo Kim, MD, PhD
Strategic Center of Cell and Bio Therapy for Heart, Diabetes and Cancer (C.-S.L., J.-W.L., J.L., Y.-W.K., H.-S.K.), Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology (C.-S.L., J.-W.L., H.-S.K.), and Cardiovascular Center and Department of Internal Medicine (H.-J.C., H.-S.K.), Seoul National University Hospital, Korea. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Korea (T.S.). Laboratory of Stem Cells and Cell Reprogramming, Department of Biomedical Engineering, Dongguk University, Seoul, Korea (H.P., J.K.).
*Drs C.-S. Lee and Cho contributed equally.
Correspondence : Hyo-Soo Kim, MD, PhD, Cardiovascular Center and Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, Seoul 110-744, Korea.
Abstract
Identification of a lineage-specific marker that enables monitoring of subsets would be valuable for establishing the conditions under which pluripotent stem cells (PSCs) differentiate into cardiac progenitor cells (CPCs) and cardiomyocytes (CMCs). The demand for PSC-derived CMCs for use in studies on cardiovascular disease has increased in recent years.1 Here, we report a new cardiac lineage marker and demonstrate its functional significance in heart development.
Key Words : cardiomyocytes, heart, pluripotent stem cells, progenitor cells
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