한빛사 논문
Hyun Yong Koh, MD, PhD1,†, Tae Hwan Kim, MD2,3,†, Youn Ho Sheen, MD, PhD4, Seung Won Lee, MD, PhD5,6,Jaewoo An, MD5, Mi Ae Kim, MD7, Man Yong Han, MD, PhD5,*, Dong Keon Yon, MD3,5,*
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
2Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea
3Medical Corps, Republic of Korea Army, Republic of Korea
4Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea
5Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
6Department of Data Science, Sejong University College of Software Convergence, Seoul, South Korea
7Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
†Hyun Yong Koh and Tae Hwan Kim contributed equally to this work.
*Co-corresponding authors
Abstract
TO THE EDITOR
Heavy metal exposure is a major public health issue that has increased during industrial development because air pollution, heavy automobile traffic, use of agricultural chemicals, contaminated irrigation water, and smoking have increased exposures via inhalation, ingestion, and skin contact.1 Heavy metal exposure is also associated with preferential biased activation of the Th2 pathway, which functions in the pathogenesis of allergic disease.2
Although nonclinical studies have identified a relationship between heavy metal exposure and allergic disease2, there is controversial epidemiologic evidence regarding the relationship of serum levels of heavy metals with asthma (positive association3, 4 and no association5, 6), atopic dermatitis (positive association7 and no association8), and airflow obstruction9, and only a few studies have investigated the effect of serum levels of heavy metals on the
development of allergic rhinitis and/or allergic multimorbidity.
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