한빛사 논문
Hyun Gyu Lim1,4, Dong Hun Kwak2,4, Sungwoo Park3,4, Sunghwa Woo1,4, Jae-Seong Yang1, Chae Won Kang1, Beomhee Kim3, Myung Hyun Noh1, Sang Woo Seo3,* & Gyoo Yeol Jung1,2,*
1 Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Korea. 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Korea. 3 School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 08826, Korea. 4These authors contributed equally: Hyun Gyu Lim, Dong Hun Kwak, Sungwoo Park, Sunghwa Woo.
*Correspondence and requests for materials should be addressed to S.W.S. or to G.Y.J.
Abstract
Although brown macroalgae holds potential as an alternative feedstock, its utilization by conventional microbial platforms has been limited due to the inability to metabolize one of the principal sugars, alginate. Here, we isolate Vibrio sp. dhg, a fast-growing bacterium that can efficiently assimilate alginate. Based on systematic characterization of the genomic information of Vibrio sp. dhg, we establish a genetic toolbox for its engineering. We also demonstrate its ability to rapidly produce ethanol, 2,3-butanediol, and lycopene from brown macroalgae sugar mixture with high productivities and yields. Collectively, Vibrio sp. dhg can be used as a platform for the efficient conversion of brown macroalgae sugars into diverse value-added biochemicals.
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