한빛사 논문
학국식품연구원, 전북대학교
Abstract
Young Jin Jang1,†,*, Jisong Ahn1,2,†, Hyo Jeong Son1, Chang Hwa Jung1,3, Jiyun Ahn1,3, Tae Youl Ha1,3*
1 Research group of Natural Materials and Metabolism, Korea Food Research Institute, Wanju-gun, 55365, Republic of Korea
2 Department of Food Science and Technology, Chonbuk National University, Jeonju-si, 54896, Republic of Korea
3 Division of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea
†These authors have contributed equally to this work.
*Correspondence: Tae Youl Ha, Young Jin Jang
Abstract
Scope
Skeletal muscle mass and quality can be negatively affected by aging, inactivity, and disease, while a loss of muscle mass is associated with chronic disease status, falls, and mortality. We investigated the effects of Hydrangea serrata on skeletal muscle mass and function, along with the underlying mechanisms.
Methods and results
Hydrangea serrata, identified through MyoD transcription activity screening, increased myogenic differentiation via Akt and p38. C57BL/6 mice were fed on a 0.25% or 0.5% Hydrangea serrata diet for 8 weeks. Hydrangea serrata increased treadmill running distance and maximum speed, as well as skeletal muscle mass. Hydrangea serrata promoted the expression of Myosin heavy chain 1 (MHC1) and MHC2A, but not MHC2B. Hydrangea serrata also upregulated the protein expression of peroxisome proliferator‐activated receptor δ (PPARδ) and mitochondrial complexes and enhanced citrate synthase and mitochondrial complex І activity. Transforming growth factor‐β (TGF‐β), myostatin, and growth differentiation factor 11 (GDF11) were attenuated by Hydrangea serrata, together with associated downstream signaling factors including phospho‐Smad3 and NADPH oxidase 4 (NOX4).
Conclusion
Hydrangea serrata enhances exercise endurance by upregulating PPARδ and downregulating TGF‐β, myostatin, and GDF11. Hydrangea serrata is a potential candidate for the development of functional food to maintain skeletal muscle mass and function.
Keywords: Hydrangea serrata; mitochondria; running endurance; skeletal muscle mass; TGF-β
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