한빛사 논문
Taegyu Kanga,b,1, Fangyuan Lic,d,1, Seungmin Baika,b,1, Wei Shaoc,d, Daishun Lingc,d,*, Taeghwan Hyeona,b,*
a Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea
b School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
c Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
d Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China
*Corresponding authors
1These authors contributed equally to this work.
Abstract
Magnetic nanoparticles (MNPs) have been extensively studied for their potential applications to cancer diagnosis and treatment. However, various obstacles limit the use of nanoparticles for delivery in the tumor microenvironment. As a viable solution to such obstacles, advances in nanoparticle surface engineering augmented by a profound understanding of cancer physiology present new opportunities for MNP-based imaging and therapeutic agents. Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. In this review, we highlight recent progress in the design of MNP-based stimuli-responsive nanomaterials and their applications to cancer diagnosis and treatment.
Keywords : Magnetic nanoparticles; Stimuli-responsive; Ligand; Controlled release; Cancer imaging; Cancer therapy
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