한빛사 논문
건국대학교, Harvard Medical School, MIT, Harvard University, King Abdulaziz University
Su Ryon Shina,b,c, Claudio Zihlmanna,b, Mohsen Akbaria,b,d, Pribpandao Assawesa,b, Louis Cheunge, Kaizhen Zhangf, Vijayan Manoharana,b, Yu Shrike Zhanga,b, Mehmet Yüksekkayag, Kai-tak Wanf, Mehdi Nikkhahh, Mehmet R. Dokmecia,b,c, Xiaowu (Shirley) Tange,* and Ali Khademhosseinia,b,c,i,j,*
aBiomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
bHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
cWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02139, USA
dDepartment of Mechanical Engineering, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 2C5, Canada
eDepartment of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Ave. West, Waterloo, Ontario N2L 3G1, Canada
fDepartment of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA
gFaculty of Engineering, Biomedical Engineering Department, Baskent University, Ankara, Turkey
hSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85251, USA
iDepartment of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia
jCollege of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 143-701, South Korea
*To whom correspondence should be addressed.
Abstract
Biomaterials currently used in cardiac tissue engineering have certain limitations, such as lack of electrical conductivity and appropriate mechanical properties, which are two parameters playing a key role in regulating cardiac cell behavior. Here, the myocardial tissue constructs are engineered based on reduced graphene oxide (rGO)‐incorporated gelatin methacryloyl (GelMA) hybrid hydrogels. The incorporation of rGO into the GelMA matrix significantly enhances the electrical conductivity and mechanical properties of the material. Moreover, cells cultured on composite rGO‐GelMA scaffolds exhibit better biological activities such as cell viability, proliferation, and maturation compared to ones cultured on GelMA hydrogels. Cardiomyocytes show stronger contractility and faster spontaneous beating rate on rGO‐GelMA hydrogel sheets compared to those on pristine GelMA hydrogels, as well as GO‐GelMA hydrogel sheets with similar mechanical property and particle concentration. Our strategy of integrating rGO within a biocompatible hydrogel is expected to be broadly applicable for future biomaterial designs to improve tissue engineering outcomes. The engineered cardiac tissue constructs using rGO incorporated hybrid hydrogels can potentially provide high‐fidelity tissue models for drug studies and the investigations of cardiac tissue development and/or disease processes in vitro.
Keywords : bioactuator, cardiac tissue engineering, gelatin, hydrogel, reduced graphene oxide
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