한빛사 논문
POSTECH
Dae-Kyum Kim1§, Byeongsoo Kang2§, Oh Youn Kim1, Dong-sic Choi1, Jaewook Lee1, Sae Rom Kim1, Gyeongyun Go1, Yae Jin Yoon2, Ji Hyun Kim1, Su Chul Jang1, Kyong-Su Park1, Eun-Jeong Choi1, Kwang Pyo Kim3, Dominic M. Desiderio4,5,6, Yoon-Keun Kim1, Jan Lötvall7, Daehee Hwang2* and Yong Song Gho 1*
1 Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Republic of Korea; 3 Department of Molecular Biotechnology, WCU Program, Konkuk University, Seoul, Republic of Korea; 4 Department of Neurology, The University of Tennessee Health Science Center, Memphis, USA; 5 Department of Molecular Science, The University of Tennessee Health Science Center, Memphis, USA; 6 The Charles B. Stout Neuroscience Mass Spectrometry Laboratory, The University of Tennessee Health Science Center, Memphis, USA; 7 Department of Internal Medicine, Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden
§The first two authors contributed equally to this work.
*Corresponding Authors
Abstract
Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20–1,000 nm, which are known to contain various bioactive molecules including proteins, lipids, and nucleic acids. Here, we present EVpedia, which is an integrated database of high-throughput datasets from prokaryotic and eukaryotic extracellular vesicles. EVpedia provides high-throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non-mammalian eukaryotic, and mammalian extracellular vesicles. In addition, EVpedia also provides an array of tools, such as the search and browse of vesicular components, Gene Ontology enrichment analysis, network analysis of vesicular proteins and mRNAs, and a comparison of vesicular datasets by ortholog identification. Moreover, publications on extracellular vesicle studies are listed in the database. This free web-based database of EVpedia (http://evpedia.info) might serve as a fundamental repository to stimulate the advancement of extracellular vesicle studies and to elucidate the novel functions of these complex extracellular organelles.
Keywords : nanocosmos, communicasomes, exosomes, microvesicles, outer membrane vesicles, membrane vesicles, web portals, phylogenetic analyses
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