한빛사 논문
Sung-Jin Park1, Beomsue Kim1, Sejong Choi2, Sivaraman Balasubramaniam1, Sung-Chan Lee1, Jung Yeol Lee3, Heon Seok Kim2, Jun-Young Kim1, Jong-Jin Kim1,4, Yong-An Lee1, Nam-Young Kang1,5, Jin-Soo Kim2,6,* & Young-Tae Chang1,3,4,*
1 Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667, Republic of Singapore. 2 Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea. 3 Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea. 4 Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea. 5 New Drug Discovery Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea. 6 Center for Genome Engineering, Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea. These authors contributed equally: Sung-Jin Park, Beomsue Kim, Sejong Choi.
*Correspondence and requests for materials should be addressed to J.-S.K. or to Y.-T.C.
Abstract
Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기