한빛사 논문
Yuhee Chung1, Yang Zhu1, Miin-Feng Wu1,4, Sara Simonini2,5, Andre Kuhn2, Alma Armenta-Medina3, Run Jin1, Lars Østergaard2, C. Stewart Gillmor3 & Doris Wagner1,*
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. 2 Crop Genetics Dept, John Innes Centre, Norwich Research Park, NR4 7UH Norwich, Norfolk, UK. 3 Laboratorio Nacional de Genomica para la Biodiversidad (Langebio), Unidad de Genomica Avanzada, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV-IPN), Irapuato C.P. 36824, Guanajuato, Mexico. 4 Present address: Bayer Crop Science, St. Louis, MO 63146, USA. 5 Present address: Department of Plant and Microbial Biology, University of Zurich, Zollikerstrasse 107, CH-8008 Zurich, Switzerland
*Correspondence and requests for materials should be addressed to D.W.
Abstract
Specification of new organs from transit amplifying cells is critical for higher eukaryote development. In plants, a central stem cell pool maintained by the pluripotency factor SHOOTMERISTEMLESS (STM), is surrounded by transit amplifying cells competent to respond to auxin hormone maxima by giving rise to new organs. Auxin triggers flower initiation through Auxin Response Factor (ARF) MONOPTEROS (MP) and recruitment of chromatin remodelers to activate genes promoting floral fate. The contribution of gene repression to reproductive primordium initiation is poorly understood. Here we show that downregulation of the STM pluripotency gene promotes initiation of flowers and uncover the mechanism for STM silencing. The ARFs ETTIN (ETT) and ARF4 promote organogenesis at the reproductive shoot apex in parallel with MP via histone-deacetylation mediated transcriptional silencing of STM. ETT and ARF4 directly repress STM, while MP acts indirectly, through its target FILAMENTOUS FLOWER (FIL) . Our data suggest that - as in animals- downregulation of the pluripotency program is important for organogenesis in plants.
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