한빛사 논문
Wooseok Songa, Minju Jooa, Ji-Hyun Yeoma, Eunkyoung Shinb, Minho Leea, Hyung-Kyoon Choib, Jihwan Hwangc, Yong-In Kimd, Ramin Seod,e, J. Eugene Leed, Christopher J. Mooref, Yong-Hak Kimg, Seong-il Eyuna, Yoonsoo Hahna, Jeehyeon Baeb,* & Kangseok Leea,*
aDepartment of Life Science, Chung-Ang University, Seoul, Republic of Korea
bSchool of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
cDepartment of Microbiology, Pusan National University, Busan, Republic of Korea
dCenter for Bioanalysis, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea
eDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
fDepartment of Genetics, Stanford University, Stanford, CA, USA
gDepartment of Microbiology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
These authors contributed equally: Wooseok Song, Minju Joo, Ji-Hyun Yeom, Eunkyoung Shin and Minho Lee.
*Correspondence to Jeehyeon Bae or Kangseok Lee
Abstract
It is generally assumed that each organism has evolved to possess a unique ribosomal RNA (rRNA) species optimal for its physiological needs. However, some organisms express divergent rRNAs, the functional roles of which remain unknown. Here, we show that ribosomes containing the most variable rRNAs, encoded by the rrnI operon (herein designated as I-ribosomes), direct the preferential translation of a subset of mRNAs in Vibrio vulnificus, enabling the rapid adaptation of bacteria to temperature and nutrient shifts. In addition, genetic and functional analyses of I-ribosomes and target mRNAs suggest that both I-ribosomal subunits are required for the preferential translation of specific mRNAs, the Shine-Dalgarno sequences of which do not play a critical role in I-ribosome binding. This study identifies genome-encoded divergent rRNAs as regulators of gene expression at the ribosome level, providing an additional level of regulation of gene expression in bacteria in response to environmental changes.
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