한빛사 논문
Changwoo Seo1,2,*, Akash Guru1,2,*, Michelle Jin1,†, Brendan Ito1, Brianna J. Sleezer1, Yi-Yun Ho1,2, Elias Wang1,‡, Christina Boada1,§, Nicholas A. Krupa1, Durgaprasad S. Kullakanda1, Cynthia X. Shen1, Melissa R. Warden 1,2,¶
1 Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.
2 Cornell Neurotech, Cornell University, Ithaca, NY 14853, USA.
* These authors contributed equally to this work.
† Present address: Neurobiology of Relapse Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, Baltimore, MD 21224, USA.
‡ Present address: Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
§ Present address: School of Medicine, New York University, New York, NY 10016, USA.
¶ Corresponding author : Melissa R. Warden
Abstract
Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is coasting across the sky. Although serotonin has been implicated in adaptive behavior, environmental regulation of its functional role remains poorly understood. In mice, we found that stimulation of dorsal raphe serotonin neurons suppressed movement in low- and moderate-threat environments but induced escape behavior in high-threat environments, and that movement-related dorsal raphe serotonin neural dynamics inverted in high-threat environments. Stimulation of dorsal raphe γ-aminobutyric acid (GABA) neurons promoted movement in negative but not positive environments, and movement-related GABA neural dynamics inverted between positive and negative environments. Thus, dorsal raphe circuits switch between distinct operational modes to promote environment-specific adaptive behaviors.
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