Characteristic gene alterations in primary gastrointestinal T- and NK-cell lymphomas
Authors and Affiliations
To the Editor:
Systemic T and natural killer (NK) cell lymphomas (systemic TNKLs) are malignancies stemming from lymphocytes of T- and NK-cell lineage that preferentially occur in East Asians. Despite an aggressive nature and poor patient outcomes, their rarity and histological heterogeneity have limited the development of effective therapeutic options. Several subtypes have been described for TNKLs according to their cellular origin and site of occurrence: these include angioimmunoblastic T-cell lymphoma (lymph nodes) and extranodal NK/T-cell lymphoma (ENKTL) (nasal/paranasal sites of the head/neck). Some TNKLs, such as enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), are frequently found along the gastrointestinal (GI) tract and are known to be more aggressive, with patients experiencing bleak clinical outcomes . While this might indicate a site-specific preference in the formation and progression of TNKLs, the molecular biology underlying such preference has not been fully elucidated. In this study, we sought to investigate genetic alterations in primary GI-TNKLs in a comparative manner to characterize the molecular features thereof and to gain insights into the site-specific tumorigenesis of TNKLs.