한빛사 논문
Eugene Lih†∇, Wooram Park‡∇ , Ki Wan Park†§, So Young Chun∥, Hyuncheol Kim§, Yoon Ki Joung† , Tae Gyun Kwon⊥, Jeffrey A. Hubbell*# , and Dong Keun Han*‡
† Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
‡ Department of Biomedical Science, College of Life Sciences, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea
§ Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Republic of Korea
∥ BioMedical Research Institute, Kyungpook National University Hospital, Daegu 41944, Republic of Korea
⊥ Department of Urology, School of Medicine, Kyungpook National University, Daegu 37224, Republic of Korea
# Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States
*Corresponding Authors
Author Contributions
∇E.L. and W.P. equally contributed to this work.
Abstract
Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH)2), and decellularized renal extracellular matrix (ECM). The Mg(OH)2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH)2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH)2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.
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