한빛사 논문
단국대학교
Kapil D. Patelab Rajendra K. Singhab and Hae-Won Kim*abcd
a Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, South Korea
b Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, South Korea
c Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, South Korea
d UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, South Korea
*Corresponding author
Abstract
Carbon-based nanomaterials include fullerenes, carbon nanotubes, graphene and its derivatives, graphene oxide, nanodiamonds, and carbon-based quantum dots. Due to their unique structural dimensions and excellent mechanical, electrical, thermal, optical and chemical properties, these materials have attracted significant interest in diverse areas, including biomedical applications. Among them, there has been recent focus on the imaging of cells and tissues and the delivery of therapeutic molecules for disease treatment and tissue repair. The broad-range one-photon property of carbon based-nanomaterials together with their biocompatibility and ease of functionalization has made them candidate imaging agents for tumor diagnosis. In particular, the intrinsic two-photon fluorescence property of carbon based-nanomaterials in the long wavelength region (near-infrared II) allows deep-tissue optical imaging. This review highlights the recent development on carbon based-nanomaterials in the field of one-photon and two-photon imaging and discusses their possible and promising diagnostic and therapeutic applications for the treatment of various diseases including cancer.
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