한빛사 논문
Abstract
Young Jun Koh1, Shinae Kang1, Hyuek Jong Lee1, Tae-Saeng Choi2, Ho Sub Lee3, Chung-Hyun Cho4 and Gou Young Koh1
1National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. 2Department of Microbiology, College of Medicine, Dankook University, Chonan, Republic of Korea. 3Department of Physiology, College of Oriental Medicine, Wonkwang University, Iksan, Republic of Korea. 4Department of Physiology, College of Medicine, Choongnam University, Daejeon, Republic of Korea.
Address correspondence to: Gou Young Koh, Department of Biological Sciences, KAIST, 373-1, Guseong-dong, Daejeon, 305-701, Republic of Korea. Phone: 82-42-869-2638; Fax: 82-42-869-2610
Received for publication April 25, 2007, and accepted in revised form September 19, 2007.
Little is known about whether bone marrow-derived circulating progenitor cells (BMDCPCs) can transdifferentiate into adipocytes in adipose tissues or play a role in expanding adipocyte number during adipose tissue growth. Using a mouse bone marrow transplantation model, we addressed whether BMDCPCs can transdifferentiate into adipocytes under standard conditions as well as in the settings of diet-induced obesity, rosiglitazone treatment, and exposure to G-CSF. We also addressed the possibility of transdifferentiation to adipocytes in a murine parabiosis model. In each of these settings, our findings indicated that BMDCPCs did not transdifferentiate into either unilocular or multilocular adipocytes in adipose tissues. Most BMDCPCs became resident and phagocytic macrophages in adipose tissues - which resembled transdifferentiated multilocular adipocytes by appearance, but displayed cell surface markers characteristic for macrophages - in the absence of adipocyte marker expression. When exposed to adipogenic medium in vitro, bone marrow cells differentiated into multilocular, but not unilocular, adipocytes, but transdifferentiation was not observed in vivo, even in the contexts of adipose tissue regrowth or dermal wound healing. Our results suggest that BMDCPCs do not transdifferentiate into adipocytes in vivo and play little, if any, role in expanding the number of adipocytes during the growth of adipose tissues.
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