한빛사 논문
Nigel G. Kooreman1, 2, 3, 4, 13, Youngkyun Kim1, 2, 3, 7, 13, Patricia E. de Almeida1, 2, 3, Vittavat Termglinchan1, 2, 3, Sebastian Diecke8, 9, 10, Ning-Yi Shao1, 2, 3, Tzu-Tang Wei1, 2, 3, Hyoju Yi1, 2, 3, 7, Devaveena Dey1, 2, 3, Raman Nelakanti1, 2, 3, Thomas P. Brouwer1, 2, 3, 4, David T. Paik1, 2, 3, Idit Sagiv-Barfi5, Arnold Han6, 11, 12, Paul H.A. Quax4, Jaap F. Hamming4, Ronald Levy5, *, Mark M. Davis6, 11, 12, *, Joseph C. Wu1, 2, 3, 14, *
1 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
2 Stanford Cardiovascular Institute of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
3 Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
4 Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands
5 Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
6 Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA
7 Convergent Research Consortium for Immunologic Disease, Seoul St. Mary’s Hospital, Catholic University of Korea, Seoul 06591, Korea
8 Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rossle Strasse 10, 13125 Berlin, Germany
9 DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany
10 Berlin Institute of Health (BIH), Berlin, Germany
11 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
12 The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
13 These authors contributed equally
14 Lead Contact
*Corresponding author
Abstract
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesothelioma, and melanoma models. As an adjuvant, the iPSC vaccine inhibited melanoma recurrence at the resection site and reduced metastatic tumor load, which was associated with fewer Th17 cells and increased CD11b+GR1hi myeloid cells. Adoptive transfer of T cells isolated from vaccine-treated tumor-bearing mice inhibited tumor growth in unvaccinated recipients, indicating that the iPSC vaccine promotes an antigen-specific anti-tumor T cell response. Our data suggest an easy, generalizable strategy for multiple types of cancer that could prove highly valuable in clinical immunotherapy.
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