한빛사 논문
Jeroen Leijtena, b, c, 1, Jungmok Seoa, b, d, 1, Kan Yuea, b, 1, Grissel Trujillo-de Santiagoa, b, e, f, Ali Tamayola, b, Guillermo U. Ruiz-Esparzaa, b, Su Ryon Shina, b, Roholah Sharifia, b, Iman Noshadia, b, i, Mario Moises Alvareza, b, e, f, Yu Shrike Zhanga, b, Ali Khademhosseinia, b, g, h,*
a Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA
b Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
c Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
d Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
e Microsystems Technologies Laboratories, MIT, Cambridge, 02139, MA, USA
f Centro de Biotecnologia-FEMSA, Tecnologico de Monterrey , CP 64849, Monterrey, Nuevo Leon, Mexico
g Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea
h Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia
i Department of Chemical Engineering, Henry M. Rowan School of Engineering, Rowan University, Glassboro, NJ 08028, USA
1 These authors contributed equally to this work.
*Corresponding author
Abstract
Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the evolution of next-generation engineered tissues.
Keywords : Hydrogel; Tissue engineering; Microfabrication; Bioprinting; Cell-biomaterial interaction; Biomaterials; Cellular microenvironments
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