한빛사 논문
건국대학교, Harvard Medical School, Brigham and Women's Hospital, MIT, King Abdulaziz University
Jeroen Rouwkema1,2,3,*, Ali Khademhosseini1,2,4,5,6,*
1Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02115, USA
2Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02319, USA
3Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
4Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA, 02155, USA
5College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea
6Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia
*Correspondence
Abstract
Trends
Engineered tissues of a clinically relevant size need a vascular network to supply the cells with nutrients and oxygen. Including a vascular network before implantation can aid in this need, by connecting to the vasculature of the patient.
To supply all cells with sufficient nutrients, and to successfully connect to the patient vasculature, the engineered vascular network needs to be highly organized. Using microfabrication technology such as photo patterning and bioprinting, the initial organization of vascular networks can be designed and controlled.
The geometry of vascular networks can also be controlled by adapting local microenvironments. The patterning of mechanical signals, fluid flows, or the availability of growth factors leads to directed vascular organization.
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