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Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
 Authors and Affiliations  Authors and Affiliations
Sungjun Park1,*, Seungwon Lee2,*, Choong-Gu Lee3,*, Guk Yeol Park1, Hyebeen Hong1, Jeon-Soo Lee1, Young Min Kim1, Sung Bae Lee4, Daehee Hwang5, Youn Soo Choi6,7, John D. Fryer8, Sin-Hyeog Im1,2,3, Seung-Woo Lee1,2 & Yoontae Lee1,2
1Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 73673, Republic of Korea. 2Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk 73673, Republic of Korea. 3Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Gyeongbuk 73673, Republic of Korea. 4Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea. 5 Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 42988, Republic of Korea. 6Department of Biomedical Sciences, Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. 7 Transplantation Research Institute, Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. 8Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.
* These authors contributed equally to this work.
Correspondence to Sin-Hyeog Im or Seung-Woo Lee or Yoontae Lee
Abstract
High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of TFH cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null TFH cells and knockdown of Etv5 suppresses the enhanced TFH cell differentiation in Cic-deficient CD4+ T cells, suggesting that Etv5 is a critical CIC target gene in TFH cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC-ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates TFH cell development and autoimmunity.
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Google (by Choong-Gu Lee)
Pubmed (by Choong-Gu Lee)
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