한빛사 논문
Charles-Francois V. Latchoumane1, 2, 6, Hong-Viet V. Ngo3, 4, 6, Jan Born3, 5,*, Hee-Sup Shin1, 2, 7,*
1 Center for Cognition and Sociality, Institute for Basic Science, Yuseong-gu, 34141 Daejeon, Republic of Korea
2 IBS school, University of Science and Technology, 34113 Daejeon, Republic of Korea
3 Institute for Medical Psychology and Behavioral Neurobiology, University of Tuebingen, 72076 Tuebingen, Germany
4 School of Psychology, University of Birmingham, B15 2TT Birmingham, UK
5 Center for Integrative Neuroscience, University of Tubingen, 72076 Tuebingen, Germany
6 These authors contributed equally
7 Lead Contact
*Corresponding author : Jan Born, Hee-Sup Shin
Abstract
While the interaction of the cardinal rhythms of non-rapid-eye-movement (NREM) sleep-the thalamo-cortical spindles, hippocampal ripples, and the cortical slow oscillations-is thought to be critical for memory consolidation during sleep, the role spindles play in this interaction is elusive. Combining optogenetics with a closed-loop stimulation approach in mice, we show here that only thalamic spindles induced in-phase with cortical slow oscillation up-states, but not out-of-phase-induced spindles, improve consolidation of hippocampus-dependent memory during sleep. Whereas optogenetically stimulated spindles were as efficient as spontaneous spindles in nesting hippocampal ripples within their excitable troughs, stimulation in-phase with the slow oscillation up-state increased spindle co-occurrence and frontal spindle-ripple co-occurrence, eventually resulting in increased triple coupling of slow oscillation-spindle-ripple events. In-phase optogenetic suppression of thalamic spindles impaired hippocampus-dependent memory. Our results suggest a causal role for thalamic sleep spindles in hippocampus-dependent memory consolidation, conveyed through triple coupling of slow oscillations, spindles, and ripples.
Keywords : NREM sleep; contextual memory consolidation; sleep spindles; slow oscillations; sharp wave-ripples; closed-loop optogenetic; thalamic reticular nucleus; prefrontal cortex; hippocampus
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기