한빛사 논문
Hyun Jung KIM1#, Seok Hoon MOON2#, Sang Hyun CHO2, Jeong Deuk LEE2 and Hei Sung KIM2
1Department of Preventive Medicine, Korea University College of Medicine, Seoul, and 2Department of Dermatology, Incheon St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
#These authors contributed equally to this work.
Abstract
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20-2.00; p<0.001) after treatment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94 (95% CI 0.10-1.79; p = 0.03). Side-effects were minor, with a few cases reporting hypomenorrhoea, mild abdominal discomfort, and transient skin irritation. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
Key words: tranexamic acid; melasma: systematic review; meta-analysis
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