한빛사 논문
Abstract
Heehwa G. Son1,*, Mihwa Seo1,2,3,*, Seokjin Ham1, Wooseon Hwang1, Dongyeop Lee1, Seon Woo A. An1, Murat Artan4, Keunhee Seo1, Rachel Kaletsky5, Rachel N. Arey5, Youngjae Ryu6, Chang Man Ha6, Yoon Ki Kim7,8, Coleen T. Murphy5, Tae-Young Roh1,9, Hong Gil Nam3,10 & Seung-Jae V. Lee1,2,4
1 Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea. 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea. 3 Center for Plant Aging Research, Institute for Basic Science, Daegu 42988, South Korea. 4 Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea. 5 Department of Molecular Biology & LSI Genomics, Princeton University, Princeton, New Jersey 08544, USA. 6 Research Division, Korea Brain Research Institute, Daegu 41068, South Korea. 7 Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, South Korea. 8 Division of Life Sciences, Korea University, Seoul 02841, South Korea. 9 Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, South Korea. 10 Department of New Biology, DGIST, Daegu 42988, South Korea.
* These authors contributed equally to this work.
Correspondence to Hong Gil Nam or Seung-Jae V. Lee.
Abstract
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations.
논문정보
관련 링크
연구자 ID
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기