한빛사 논문
Abstract
Suk Ho Bhang1, Woo Soon Jang2, Jin Han3, Jeong-Kee Yoon3, Wan-Geun La3, Eungkyu Lee4,5, Youn Sang Kim4,5, Jung-Youn Shin3, Tae-Jin Lee3, Hong Koo Baik2,* and Byung-Soo Kim3,6,*
1 Sungkyunkwan University, Suwon, Republic of Korea
2 Department of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea
3 School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
4 Program in Nano Science and TechnologyGraduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea
5 Advanced Institutes of Convergence Technology, Suwon, Republic of Korea
6 Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
S.H.B., W.S.J., and J.H. contributed equally to this work
*Corresponding authors
Abstract
Current treatments for wound healing engage in passive healing processes and rarely participate in stimulating skin cell behaviors for active wound healing. Electric potential difference-derived electrical fields (EFs) are known to modulate skin cell behaviors. Here, a piezoelectric dermal patch is developed that can be applied on skin wound site and EF is generated to promote wound healing. The one-directionally aligned zinc oxide nanorod-based piezoelectric patch generates piezoelectric potential upon mechanical deformations induced by animal motion, and induces EF at the wound bed. In vitro and in vivo data demonstrate that the piezoelectric patch promotes the wound healing process through enhanced cellular metabolism, migration, and protein synthesis. This modality may lead to a clinically relevant piezoelectric dermal patch therapy for active wound healing.
Keywords : dermal patches; electric fields; piezoelectricity; wound healing; zinc oxide
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