Mikyung Shin1, Sung-Gurl Park2, Byung-Chang Oh3, Keumyeon Kim4, Seongyeon Jo4, Moon Sue Lee4, Seok Song Oh5, Seon-Hui Hong6, Eui-Cheol Shin6, Ki-Suk Kim2,7, Sun-Woong Kang2,7*† and Haeshin Lee1,3,4*†
1The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea. 2Predictive Model Research Center, Korea Institute of Toxicology (KIT), Daejeon 34114, Republic of Korea. 3Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea. 4R&D Center, InnoTherapy Inc., Seoul 07327, Republic of Korea. 5Meta-Biomed Co., Cheongju, Chungbuk 28161, Republic of Korea. 6Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea. 7Department of Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Republic of Korea.
†These authors contributed equally to this work.
*Correspondence to : Sun-Woong Kang or Haeshin Lee
Bleeding is largely unavoidable following syringe needle puncture of biological tissues and, while inconvenient, this typically causes little or no harm in healthy individuals. However, there are certain circumstances where syringe injections can have more significant side effects, such as uncontrolled bleeding in those with haemophilia, coagulopathy, or the transmission of infectious diseases through contaminated blood. Herein, we present a haemostatic hypodermic needle able to prevent bleeding following tissue puncture. The surface of the needle is coated with partially crosslinked catechol-functionalized chitosan that undergoes a solid-to-gel phase transition in situ to seal punctured tissues. Testing the capabilities of these haemostatic needles, we report complete prevention of blood loss following intravenous and intramuscular injections in animal models, and 100% survival in haemophiliac mice following syringe puncture of the jugular vein. Such self-sealing haemostatic needles and adhesive coatings may therefore help to prevent complications associated with bleeding in more clinical settings.