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Abstract
Ji-Hoon Kim1, Gi-Chan Han1, Ji-Yun Seo1, Inkuk Park1, Wookjin Park1, Hyun-Woo Jeong1, Su Hyeon Lee2, Sung-hwan Bae1, Jinwoo Seong1, Min-Kyu Yum1, Sang-Hyeon Hann1, Young-Guen Kwon3, Daekwan Seo1,4, Man Ho Choi2 and Young-Yun Kong1,5
1School of Biological Sciences, Seoul National University, Seoul 151-747, South Korea. 2Materials and Life Science Research Division, Korea Institute of Science and Technology, Seoul 136-791, South Korea. 3Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-752, South Korea. 4Center for RNA Research Institute for Basic Science, Seoul 151-742, South Korea.
5Correspondence should be addressed to Y.Y.K.
Abstract
Quiescent satellite cells, known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle following injury throughout life. Although they mainly originate from multipotent stem/progenitor cells of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb 1 (Mib1) expression in myofibres at puberty, which activates Notch signalling in cycling juvenile satellite cells and causes them to be converted into adult quiescent satellite cells. Myofibres lacking Mib1 fail to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Our findings reveal that the hypothalamic?pituitary?gonadal axis drives Mib1 expression in the myofibre niche. Moreover, the same axis regulates the re-establishment of quiescent satellite cell populations following injury. Our data show that sex hormones establish adult quiescent satellite cell populations by regulating the myofibre niche at puberty and re-establish them during regeneration.
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