Yoonhee Jin1, Jungmok Seo2, Jung Seung Lee1, Sera Shin2, Hyun-Ji Park1, Sungjin Min1, Eunji Cheong1, Taeyoon Lee2,* and Seung-Woo Cho1,3,*
1 Department of Biotechnology, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea
2 School of Electrical and Electronic Engineering, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea
3 Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea
Y.J. and J.S. contributed equally to this work.
Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion efficiency, and induces highly matured neuronal phenotypes with improved electrophysiological functionalities. TENG devices may also be used for biomedical in vivo reprogramming.
Keywords : induced neuronal cells; in vivo reprogramming; neuronal maturation; nonviral direct conversion; triboelectric nanogenerators