한빛사 논문
Abstract
Hye Soon Park, Jee Hye Han, Kyung Mook Choi, and Seon Mee Kim*
From the Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (HSP); the Department of Family Medicine, Eulji General Hospital, Eulji Medical University, Seoul,
Korea (JHH); and the Departments of Internal Medicine (KMC) and Family Medicine (SMK), College of Medicine, Korea University, Seoul, Korea.
*Address reprint requests and correspondence to Seon Mee Kim, Department of Family Medicine, Ansan Hospital, College of Medicine, Korea University, 516 Kojan-Dong, Ansan City, Kyungki-Do, 425-020, South Korea.
Abstract
BACKGROUND:
Concern is growing about nonalcoholic fatty liver disease, not only because it is a common liver disorder but also because it is one of the leading causes of chronic liver disease. Unexplained elevations in aminotransferase concentrations have been strongly associated with adiposity and thus may represent nonalcoholic fatty liver disease.
OBJECTIVE:
We investigated the relation between nonviral or nonalcoholic elevations in alanine aminotransferase (ALT) and the metabolic syndrome in Korean adolescents.
DESIGN:
Data were obtained from 1594 subjects aged 10-19 y from the Korean National Health and Nutrition Examination Survey 1998, a cross-sectional health survey of a nationally representative sample of noninstitutionalized civilian South Koreans. Body mass index, waist circumference, blood pressure, fasting glucose, lipid profiles, and serum ALT were measured.
RESULTS:
The prevalence of elevated ALT (> 40 U/L) was 3.6% in boys and 2.8% in girls. The prevalence of metabolic syndrome was 3.3% in both boys and girls. The components of the metabolic syndrome were significantly worse in the group with elevated ALT concentrations than in the group with normal ALT concentrations. The odds ratios (95% CIs) for elevated ALT were 6.6 (3.7, 11.8), 2.3 (1.2, 4.6), and 3.0 (1.6, 5.8) in the adolescents with abdominal obesity, high triacylglycerol concentrations, and low HDL-cholesterol concentrations, respectively. The odds ratios for elevated ALT were 1.5 (0.7, 3.1), 2.6 (1.1, 6.2), and 6.2 (2.3, 16.8) in the adolescents with 1, 2, and > or = 3 risk factors (metabolic syndrome), respectively.
CONCLUSION:
The metabolic syndrome was strongly associated with elevated ALT concentrations in Korean adolescents, and this association existed in a graded fashion across the number of metabolic components.
KEY WORDS : Nonalcoholic fatty liver disease, aminotransferase, metabolic syndrome, adolescents, Korea
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