한빛사 논문
Abstract
Jin-Young Yang,1,9 Min-Soo Kim,2,9 Eugene Kim,1,9 Jae Hee Cheon,3,9 Yong-Soo Lee,1 Yeji Kim,1 Su-Hyun Lee,1 Sang-Uk Seo,4 Seung-Ho Shin,5 Sun Shim Choi,5 Bumseok Kim,6 Sun-Young Chang,7 Hyun-Jeong Ko,8 Jin-Woo Bae,2,* and Mi-Na Kweon1,*
1Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul 05505, Korea
2Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul 02447, Korea
3Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 03722l, Korea
4Department of Medicine, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul 03080, Korea
5Department of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea
6Laboratory of Pathology (BK21 Plus Program), College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea
7Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon 16499, Korea
8Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea
9Co-first author
*Correspondence: Jin-Woo Bae, Mi-Na Kweon
Summary
Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice. DSS-induced colitis was associated with altered enteric viral abundance and composition. When wild-type mice were reconstituted with Toll-like receptor 3 (TLR3) or TLR7 agonists or inactivated rotavirus, colitis symptoms were significantly ameliorated. Mice deficient in both TLR3 and TLR7 were more susceptible to DSS-induced experimental colitis. In humans, combined TLR3 and TLR7 genetic variations significantly influenced the severity of ulcerative colitis. Plasmacytoid dendritic cells isolated from inflamed mouse colon produced interferon-β in a TLR3 and TLR7-dependent manner. These results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation.
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TOP52016년 선정
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