Su Ryon Shina, b, c, 1, Yi-Chen Lia, b, c, 1, HaeLin Janga, b, Parastoo Khoshakhlagha, b, c, Mohsen Akbaria, b, Amir Nasajpoura, b, Yu Shrike Zhanga, b, c, Ali Tamayola, b, c, Ali Khademhosseinia, b, c, d, e,*
a Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA
b Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
c Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
d Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia
e College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea
1 S.R. Shin and Y.C. Li contributed equally to this work.
Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and a model system for quantum behavior. The material's excellent electrical conductivity, biocompatibility, surface area and thermal properties are of much interest to the scientific community. Two dimensional graphene materials have been widely used in various biomedical research areas such as bioelectronics, imaging, drug delivery, and tissue engineering. In this review we will highlight the recent applications of graphene-based materials in tissue engineering and regenerative medicine. In particular, we will discuss the application of graphene-based materials in cardiac, neural, bone, cartilage, skeletal muscle, and skin/adipose tissue engineering. We also discuss the potential risk factors of graphene-based materials in tissue engineering. In addition, we will outline the opportunities in the usage of graphene-based materials for clinical applications.