[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보  |  e브릭몰e브릭몰 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
물리적 거리두기 실천
스폰서배너광고 안내  배너1 배너2 배너3 배너4
LABox-과학으로 본 코로나19 (COVID-19)
전체보기 한빛사논문 추천논문 인터뷰 그이후 한빛사통계
김유신
김유신 (Yoo-Shin Kim) 저자 이메일 보기
경북대학교
저자CV 보기
330 KB
 
조회 1211  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel
Jong-Ho Kima, d, 1, Yoo-Shin Kimb, c, 1, Sungwon Kima, d, Jae Hyung Parke, Kwangmeyung Kima, d, Kuiwon Choia, Hesson Chunga, Seo Young Jeongf, Rang-Woon Parkb, c, In-San Kimb, c, Ick Chan Kwona, d

a Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, South Korea
b Department of Biochemistry, School of Medicine, Kyungpook National University, Dong-In 2-101, Jung-gu, Daegu 700-422, South Korea
c Advanced Medical Technology Cluster for Diagnosis and Prediction, 101 Dong-In 2-101, Jung-gu, Daegu 700-422, South Korea
d KIST Regional Laboratory in Advanced Medical Technology Cluster for Diaganosis and Prediction, 101 Dong-In 2-101, Jung-gu, Daegu 700-422, South Korea
e Department of Advanced Polymer and Fiber Materials, College of Environment and Applied Chemistry, KyungHee University, Gyeonggi-do 449-701, South Korea
f Department of Pharmaceutics, College of Pharmacy, Kyung Hee University, 1 Hoegi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea

Abstract
Self-assembled nanoparticles based on hydrophobically modified glycol chitosan (HGC) were prepared as a carrier for paclitaxel. HGC conjugates were prepared by chemically linking 5β-cholanic acid to glycol chitosan chains using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide chemistry. In phosphate-buffered saline (PBS; pH 7.4), the synthesized HGC conjugates formed nano-sized particles with a diameter of 200 nm and exhibited high thermodynamic stability as reflected by their low critical aggregation concentration (0.03 mg/ml). Paclitaxel was efficiently loaded into HGC nanoparticles up to 10 wt.% using a dialysis method. The paclitaxel-loaded HGC (PTX-HGC) nanoparticles were 400 nm in diameter and were stable in PBS for 10 days. These PTX-HGC nanoparticles also showed sustained release of the incorporated of paclitaxel (80% of the loaded dose was released in 8 days at 37 °C in PBS). Owing to sustained release, the PTX-HGC nanoparticles were less cytotoxic to B16F10 melanoma cells than free paclitaxel formulated in Cremophor EL. Injection of PTX-HGC nanoparticles into the tail vein of tumor-bearing mice prevented increases in tumor volume for 8 days. Finally, PTX was less toxic to the tumor-bearing mice when formulated in HGC nanoparticles than when formulated with Cremophor EL.

Keywords : Hydrophobically modified glycol chitosan; Paclitaxel; Nanoparticles; In vivo anti-tumor effect

논문정보
- 형식: Research article
- 게재일: 2006년 03월 (BRIC 등록일 2016-02-19)
- 연구진: 국내연구진태극기
- 피인용횟수: 120회 이상 인용된 논문
세포 형광 이미징 멀티플렉싱을 위한 초고속 사이클링[Angew. Chem.-Int. Edit.]
고진아
발표: 고진아 (Massachusetts General Ho...)
일자: 2020년 4월 14일 (화) 오전 10시 (한국시간)
언어: 영어
참석자 접수신청하기
The presenting symptoms of cancer and stage at diagnosis[Lancet Oncol.]
구민정
발표: 구민정 (University College Londo...)
일자: 2020년 4월 20일 (월) 오후 04시 (한국시간)
언어: 영어
참석자 접수신청하기

  댓글 0
등록
 
목록
(주)비아이코퍼레이션
관련링크
김유신 님 전체논문보기 >
관련인물
권익찬 (한국과학기술연구원(KIST)...)
김광명 (한국과학기술연구원(KIST)...)
김종호 (경희대학교)
외부링크
Google (by Yoo-Shin Kim)
Pubmed (by Yoo-Shin Kim)
프리미엄 Bio일정 Bio일정 프리미엄 안내
[BRIC Webinar]The presenting symptoms of cancer and stage at diagnosis[Lancet Oncol.]
[BRIC Webinar]The presenting symptoms of cancer and stage at diagnosis[Lancet Oncol.]
사전접수: ~2020.04.20
날짜: 2020.04.20
Online 개최
[BRIC Webinar]세포 형광 이미징 멀티플렉싱을 위한 초고속 사이클링[Angew. Chem.-Int. Edit.]
[재직자무료교육] 분석기기(HPLC) 활용 품질검사 실습(4.9~4.10) / 화장품 제형제조 기술 실습(4.13~4.14)
[재직자무료교육] 분석기기(HPLC) 활용 품질검사 실습(4.9~4.10) / 화장품 제형제조 기술 실습(4.13~4.14)
날짜: 2020.04.09~14
장소: 충청북도 청주시 흥덕구 오송읍 오송생명1로 194-41 충북산학융합본부 기업연구1관 교육장
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS
머크