Hyunjae Lee1,2,*, Youngsik Lee1,2,*, Changyeong Song1,2,*, Hye Rim Cho1,3, Roozbeh Ghaffari4, Tae Kyu Choi1,2, Kyung Hoon Kim1,2, Young Bum Lee1,2, Daishun Ling1,2,5, Hyuk Lee6, Su Jong Yu7, Seung Hong Choi1,3, Taeghwan Hyeon1,2 & Dae-Hyeong Kim1,2
1 Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea. 2 School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea. 3Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea. 4MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, USA. 5 Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China. 6Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea. 7 Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
* These authors contributed equally to this work.
Correspondence to : Seung Hong Choi or Taeghwan Hyeon or Dae-Hyeong Kim
Abstract
The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.