Wonhwa Lee1,2, Junyoung Seo2, Soyoung Kwak1, Eun Ji Park1, Dong Hee Na1, Soyoun Kim2, You Mie Lee1, In-San Kim3,4,* and Jong-Sup Bae1,2,*
1 College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea
2 Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, South Korea
3 Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea
4 KU-KIST School, Korea University, Seoul, South Korea
*Corresponding authors
Abstract
New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have the anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
Keywords : ferritin; nanoparticles; PC-gla; sepsis; TRAP