Roman A. Perez1, 2, 6, Seog-Jin Seo1, 2, 6, Jong-Eun Won1, 2, Eun-Jung Lee1, 2, Jun-Hyeog Jang4, Jonathan C. Knowles2, 5, Hae-Won Kim1, 2, 3, *
1 Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea
2 Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea
3 Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea
4 Department of Biochemistry, College of Medicine, Inha University, Incheon 400-712, Republic of Korea
5 Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
6 These authors equally contributed to this work.
*Corresponding author : Hae-Won Kim
Over the past few years, attention has been focused on the therapeutic roles in designing bone scaffolds for successful repair and regeneration. Indeed, biologically dynamic events in the bone healing process involve many of the molecules and cells adherent to the scaffold. Recent bone scaffolds have been designed considering intrinsic chemical and physical factors and exogenous/extrinsic cues that induce bone regeneration. Here, we attempt to topically review the current trends and to suggest featured strategies for the design of therapeutically relevant bone scaffolds taking into account recent studies and applications.