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Abstract
Dr. Cheol Am Hong1, Dr. Ahmed A. Eltoukhy2, Prof. Hyukjin Lee3, Prof. Robert Langer2, Prof. Daniel G. Anderson2,* and Prof. Yoon Sung Nam1,*
1 Department of Biological Sciences, Department of Materials Science and Engineering, KI for NanoCentury (KINC CNiT), Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Republic of Korea
2 Department of Biological Engineering, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA
3 Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul (Republic of Korea
* Corresponding authors
Abstract
Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.
Keywords: dendrimeric nanostructures; gene silencing; poly(β-amino ester); polymeric condensation; siRNA
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