한빛사 논문
Abstract
Jeonghun Kim1,2, Eugene Lee3,4, Yoochan Hong3, Byeonggwan Kim1,2, Minhee Ku3,5, Dan Heo3,4, Jihye Choi1, Jongbeom Na1,2, Jungmok You6, Seungjoo Haam1,7, Yong-Min Huh3,7, Jin-Suck Suh3,4,5,7,*, Eunkyoung Kim1,2,* and Jaemoon Yang3,5,7,*
1 Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea
2 Active Polymer Center for Pattern Integration, Yonsei University, Seoul, Republic of Korea
3 Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea
4 Nanomedical National Core Research Center, Yonsei University, Seoul, Republic of Korea
5 Brain Korea 21 Plus Project for Medical Science, College of Medicine, Yonsei University, Seoul, Republic of Korea
6 Department of Plant and Environmental New Resources, Kyung Hee University, Republic of Korea
7 YUHS-KRIBB Medical Convergence Research Institute, Seoul, Republic of Korea
*Correspondence to Jin-Suck Suh, Eunkyoung Kim, Jaemoon Yang
J.K. and E.L. contributed equally to this work.
Abstract
To access smart optical theragnosis for cancer, an easily processable heterocyclic conjugated polymer (poly(sodium3-((3-methyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-3-yl)methoxy)propane-1-sulfonate), PPDS) nanoassembly is fabricated by a surfactant-free one-step process, without the laborious ordinary multicoating process. The conjugated nanoassembly, with a self-doped structure, provides strong absorbance in the near-infrared (NIR) range even in a neutral pH medium and exhibits excellent stability (>six months). In addition, the prepared PPDS nanoassembly shows a high photothermal conversion efficiency of 31.4% in organic photothermal nanoparticles. In particular, the PPDS nanoassembly is stably suspended in the biological medium without any additives. Through a simple immobilization with the anti-CD44 antibody, the prepared biomarker-targetable PPDS nanoassembly demonstrates specific targeting toward CD44 (expressed in stem-like cancer cells), allowing NIR absorbance imaging and the efficient targeted photothermal damaging of CD44-expressing cancer cells, from in vitro 3D mammospheres (similar to the practical structure of tumor in the body) to in vivo xenograft mice tumor models (breast cancer and fibrosarcoma). In this study, the most simplified preparation method is for this organic conjugated polymer-based nanoassembly by a molecular approach is reported, and demonstrated as a highly promising optical nanoagent for optical cancer theragnosis.
Keywords: cancer; nanoassemblies; optical theragnosis; self-doped conjugated polymers; surfactant-free
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