한빛사 논문
Abstract
Yeongseon Jang1, Hyojin Lee2, Kookheon Char1,* and Jwa-Min Nam2,*
1 The National Creative Research Initiative Center for Intelligent Hybrids, School of Chemical and Biological Engineering, Seoul National University, Gwanak-gu, Seoul, South Korea
2 Department of Chemistry, Seoul National University, Gwanak-gu, Seoul, South Korea
*Corresponding authors
Y.J. and H.L. contributed equally to this work.
Abstract
A transparent, nanoporous, and transferable membrane-based cell coculture platform is devised and developed to be used for the accurate and versatile control and analysis of paracrine communications between cocultured cells, as well as easy isolation of each cell line for further manipulation and analysis. On the basis of the high degree of freedom in stacking and destacking of the membranes and the controllable nanopores that efficiently allow exchanges of paracrine factors without physical contact between the different cell lines, the paracrine signaling between human breast metastatic cancer cells and three different types of stromal cell types are controlled and studied.
Keywords: cancer cells; cell coculture; nanoporous membranes; paracrine signaling; stromal cells
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