한빛사 논문
Abstract
Mikyung Shin1, Ji Hyun Ryu1,2, Joseph P. Park1, Keumyeon Kim3, Jae Wook Yang4 and Haeshin Lee1,2,*
1 The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 University RdS, Daejeon, S. Korea
2 Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 University Rd, Daejeon, S. Korea
3 R&D center, InnoTherapy, Daejeon, S. Korea
4 Department of Ophthalmology, Inje University Pusan Paik Hospital, Inje University College of Medicine, Busan, S. Korea
*Corresponding Author
Abstract
DNA has emerged as a novel material in many areas of materials science due to its programmability. Especially, DNA hydrogels have been studied to incorporate new functions into gels. To date, only a few methods have been developed for fabricating DNA hydrogels, such as the use of complementary sequences or covalent bond. Herein, it is demonstrated that one of the most well-known plant-derived polyphenols, tannic acid (TA), can form a DNA hydrogel which is named TNA hydrogel (TA + DNA). TA plays a role as a “molecular glue” by a new mode of action reversibly connecting between phosphodiester bonds, which is different from the crosslinking utilizing complementary sequences. TA intrinsically degrades due to ester bonds connecting between pyrogallol groups, causing a degradable DNA hydrogel. Furthermore, TNA gel is multifunctional in that the gel is extensible upon pulling and adhesive to tissues because of the rich polyphenol groups in TA (ten phenols per TA). Unexpectedly, TNA gel exhibits superior in vivo hemostatic ability that can be useful for biomedical applications. This new DNA hydrogel preparation method represents a new technique for fabricating a large amount of DNA-based hemostatic hydrogel without chemically modifying DNA or requiring the crosslinking by complementary sequences.
Keywords: DNA; multifunctional hydrogel; hydrogels, plant-originated molecular glues; tannic acid
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