Jungmok Seo1, Jung Seung Lee2, Kihong Lee2, Dayeong Kim1, Kisuk Yang2, Sera Shin1, Chandreswar Mahata1, Hwae Bong Jung3, Wooyoung Lee3, Seung-Woo Cho2,* and Taeyoon Lee1,*
1 Nanobio Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, Seodaemun-Gu, Seoul, Republic of Korea
2 Stem Cell and Biomaterial Engineering Laboratory, Department of Biotechnology, Yonsei University, Seodaemun-Gu, Seoul, Republic of Korea
3 Nano Device Laboratory, Department of Materials Science and Engineering, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea
* Corresponding authors: Seung-Woo Cho, Taeyoon Lee
Jungmok Seo and Jung Seung Lee contributed equally to this work
A switchable water-adhesive, superhydrophobic nanowire surface is developed for the formation of functional stem cell spheroids. The sizes of hADSC spheroids are readily controllable on the surface. Our surface increases cell-cell and cell-matrix interaction, which improves viability and paracrine secretion of the spheroids. Accordingly, the hADSC spheroids produced on the surface exhibit significantly enhanced angiogenic efficacy.
Keywords: superhydrophobic surfaces; switchable water adhesion; silicon nanowires; human adipose-derived stem cells; spheroid formation