한빛사 논문
Abstract
Koo Chul Kwon1,†, Ju Hee Ryu2,†, Jong-Hwan Lee1, Eun Jung Lee1, Ick Chan Kwon2, Kwangmeyung Kim2,* and Jeewon Lee1,*
1 Department of Chemical and Biological Engineering, College of Engineering, Korea University, Seoul, Republic of Korea
2 Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea
† These authors contributed equally to this work.
*Corresponding authors
PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1?3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
Keywords: proteinticle; gold nanoparticle; core/shell; nanotoxicity; photothermal therapy
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