한빛사 논문
Abstract
Jae-Hoon Jung1*, Hyo-Jun Lee2*, Mi-Jeong Park2*, and Chung-Mo Park2,3
1 Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK
2 Department of Chemistry, Seoul National University, Seoul 151-742, Korea
3 Plant Genomics and Breeding Institute, Seoul National University, Seoul 151-742, Korea
*These authors contributed equally to this work
Corresponding author: Chung-Mo Park
The E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) functions as a cold signaling attenuator by degrading the INDUCER OF CBF EXPRESSION 1 transcription factor, which is a key regulator of the cold-induced transcriptome and freezing tolerance in plants. Recent studies demonstrate that HOS1 also plays nonproteolytic roles in gene expression regulation. HOS1 acts as a chromatin remodeling factor that modulates FLOWERING LOCUS C chromatin in cold regulation of flowering time. It associates with the nuclear pore complex to facilitate nucleocytoplasmic mRNA export to maintain circadian periodicity over a range of light and temperature conditions. In this review, we summarize recent advances in molecular mechanisms underlying HOS1 function during plant development in response to fluctuating environmental conditions.
Keywords: chromatin remodeling, circadian clock, E3 ubiquitin ligase, HOS1, mRNA export, photoperiodic flowering
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