Suk-Won Hwang†, Gayoung Park ‡, Chris Edwards §, Elise A. Corbin∥ , Seung-Kyun Kang †, Huanyu Cheng⊥ , Jun-Kyul Song †, Jae-Hwan Kim†, Sooyoun Yu#, Joanne Ng ‡, Jung Eun Lee‡, Jiyoung Kim‡, Cassian Yee¶, Basanta Bhaduri§, Yewang Su⊥¤, Fiorenzo G. Omennetto Δ, Yonggang Huang⊥, Rashid Bashir∥ , Lynford Goddard §, Gabriel Popescu §, Kyung-Mi Lee ‡*, and John A. Rogers †§■*
† Department of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
‡ Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Republic of Korea
§ Department of Electrical and Computer Engineering and Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
⊥Department of Mechanical Engineering, Civil and Environmental Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, Illinois 60208, United States
# Department of Chemical and Biomolecular Engineering,University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
¶ Department of Melanoma Medical Oncology and Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States
¤ Center for Mechanics and Materials, Tsinghua University, Beijing 100084, China
Δ Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States
■ Department of Chemistry, Mechanical Science and Engineering, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
S.-W.H. and G.P. contributed equally.
K.-M.L. and J.A.R. contributed equally.
Single-crystalline silicon nanomembranes (Si NMs) represent a critically important class of material for high-performance forms of electronics that are capable of complete, controlled dissolution when immersed in water and/or biofluids, sometimes referred to as a type of “transient” electronics. The results reported here include the kinetics of hydrolysis of Si NMs in biofluids and various aqueous solutions through a range of relevant pH values, ionic concentrations and temperatures, and dependence on dopant types and concentrations. In vitro and in vivo investigations of Si NMs and other transient electronic materials demonstrate biocompatibility and bioresorption, thereby suggesting potential for envisioned applications in active, biodegradable electronic implants.
Keywords: silicon nanomembranes; biocompatible; biodegradable; bioresorbable; transient electronics; hydrolysis