한빛사 논문
Abstract
Tae-Hyun Shin†,∥, Jin-sil Choi†,∥, Seokhwan Yun‡, Il-Sun Kim‡, Ho-Taek Song§, Youngmee Kim⊥, Kook In Park ‡*, and Jinwoo Cheon †*
† Center for Evolutionary Nanoparticles (CEN), Department of Chemistry, Yonsei University, Seoul 120-749, Korea
‡Department of Pediatrics and BK 21 and §Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 120-752, Korea
⊥ Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea
∥T.-H.S. and J.-s.C. contributed equally.
*Correspondence to Kook In Park, Jinwoo Cheon
Abstract
One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform “AND logic gate” algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
Keywords: MRI contrast agent; magnetic nanoparticle; MRI; dual-mode contrast agent; stem cell tracking
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