한빛사 논문
Abstract
Taek Lee1, Ajay Kumar Yagati2,3, Junhong Min4 and Jeong-Woo Choi2,3,*
1 Research Institute for Basic Science, Sogang University, Mapo-gu, Seoul, Republic of Korea
2 Interdisciplinary Program of Integrated Biotechnology, Sogang University, Mapo-gu, Seoul, Republic of Korea
3 Department of Chemical and Biomolecular Engineering, Sogang University, Mapo-gu, Seoul, Republic of Korea
4 School of Integrative Engineering, Chung-Ang University, Dongjak-gu, Seoul, Korea
*Correspondence: Jeong-Woo Choi
Major challenges in molecular electronics include miniaturization, and the realization of a simple function to alter silicon-based electronics. It has been hard to develop a single molecular-based computing system, since such systems need complex functionality to be developed at the single-molecular level. To develop a molecular-based biocomputing system, a bioprocessing device is demonstrated that consists of recombinant azurin/DNA/inorganic material hybrid to perform the various functions in a device. A metalloprotein which exhibits redox behavior is used as a biomemory source. The redox property could be controlled with command materials (conducting nanoparticles, heavy metal ions, and semiconducting nanoparticles) to perform ‘information reinforcement,’ ‘information regulation,’ and ‘information amplification’ functions, respectively. This bioprocessing device could be a foundation to develop single-biomolecular-based computing systems.
Keywords: protein-DNA-inorganic; hybrid materials; information regulation; bioprocessing devices
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