한빛사 논문
SeungHyun Jeon‡, Dr. Jeong-Mi Moon‡, Dr. Eun Sook Lee, Dr. Yon Hui Kim and Dr. Youngnam Cho*
New Experimental Therapeutic Branch, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do 410-769 (South Korea)
‡ These authors contributed equally to this work.
* Corresponding author
Abstract
The specific capture and remotely controlled release of the EpCAM-positive cancer cells from biotin-doped polypyrrole (Ppy) films in response to an electrical potential is presented. As Ppy allows the direct incorporation of biotin molecules during the electrochemical process, densely packed biotin molecules can serve as the binding sites for streptavidin-tagged biomolecular complexes. This study demonstrates not only the enhanced capture and enrichment of EpCAM-positive cancer cells but also “on-demand” release of the viable cells from conductive Ppy in an electrical-potential-dependent way. This novel approach is of great importance in a diverse range of applications, and in particular in cancer diagnostics and screening.
Keywords: conducting polymers; electrical stimulation; EpCAM; HeLa cells; MCF7 cells
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TOP52014년 선정
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