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Abstract
Jae-Sung Woo1,2 and V. Narry Kim1,2,*
1Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea
2School of Biological Sciences, Seoul National University, Seoul 151-742, Korea
*Corresponding author : V. Narry Kim
MeCP2 is a transcriptional regulator important for neurodevelopment and is involved in Rett syndrome and autism. In this issue of Developmental Cell, Cheng and colleagues (2014) report that MeCP2 also regulates microRNA biogenesis. MeCP2 phosphorylation induces a direct interaction with DGCR8, leading to reduced microRNA processing and retardation of dendritic growth.
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