한빛사 논문
Abstract
Hongje Jang , Young-Kwan Kim , Hyun Huh , and Dal-Hee Min*
Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Seoul 151-747, Republic of Korea
*Correspondence to Dal-Hee Min
Abstract
Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.
Keywords: cancer; dextran; doxorubicin; hollow nanoparticle; photothermal therapy
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