Seonki Hong1,‡, Jihoon Kim2,‡, Yun Suk Na1, Junghong Park2, Sunjin Kim1, Kaushik Singha2, Prof. Dr. Gun-Il Im3, Dr. Dong-Keun Han4, Prof. Dr. Won Jong Kim2,*, Prof. Dr. Haeshin Lee1,*
1 Department of Chemistry, KAIST, Daejeon, 305-701 (Republic of Korea)
2 Center for Self-assembly and Complexity, Institute for Basic Science (IBS) and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 790-784 (Republic of Korea)
3 Department of Orthopaedics, Dongguk University, Ilsan Hospital, Goyang, 411-773 (Republic of Korea)
4 Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 130-650 (Republic of Korea)
‡ These authors contributed equally to this work
*To whom correspondence should be addressed. .
† This work was supported by the NRF of S. Korea: Pioneer (2011-0001800, H.L.), Future-based Technology Development Programs (2009-0092222, H.L.), National Junior Research Fellowship (2012H1A8002613, S.H.), and the Institute for Basic Science (IBS) (W.J.K.). This work is also supported by the Ministry of Health & Welfare (A120170, H.L.).
Capture and release: The material-independent surface chemistry of a poly(norepinephrine) (pNE) which exhibits perfect smoothness at the nanometer scale is controlled by 3,4-dihydroxybenzaldehyde-norepinephrine (DHBA-NE) conjugates. The pNE layer containing DHBA-NE serves to store and release small therapeutics such as nitric oxide.
Keywords: drug delivery; bioinspired chemistry; nitric oxide; polymers; surface chemistry