한빛사 논문
Vu Ngoc Phan1,†,‡, Eun-Kyung Lim2,‡, Taekhoon Kim1,‡, Minsik Kim1, Yuna Choi2, Byeongyoon Kim1, Myounghoon Lee2, Aram Oh1, Juhong Jin1, Youngjoo Chae1, Hionsuck Baik3, Jin-Suck Suh2, Seungjoo Haam4, Yong-Min Huh2,*, Kwangyeol Lee1,*
1Department of Chemistry and Research Institute for Natural Sciences, Korea University, Seoul 136-701, Korea
2Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Korea
3Korea Basic Science Institute (KBSI), Seoul 136-713, Korea
4Department of Chemical & Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
† Present address : Advanced Institute for Science and Technology, Hanoi University of Science and Technology, Hanoi, Vietnam
*To whom correspondence should be addressed.
‡These authors contributed equally to this work.
Abstract
Hollow Mn-doped iron oxide nanocontainers, formed by a novel one-pot synthetic process, fulfill the dual requirements of delivering an effective dose of an anticancer drug to tumor tissue and enabling image-contrast monitoring of the nanocontainer fate through T2-weighted magnetic resonance imaging, thereby determining the optimal balance between diagnostic and therapeutic moieties in an all-in-one theranostic nanoplatform.
Keywords: anisotropic etching; hydrophobic cavities; nanocontainers; magnetic resonance imaging;theranostics
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