한빛사 논문
Muthunarayanan Muthiaha, b, In- Kyu Parka, b, Chong-Su Choc
a Department of Biomedical Sciences and Center for Biomedical Human Resources (BK-21 project), Chonnam National University Medical School, Gwangju 501-757, South Korea
b Clinical Vaccine R&D Center, Chonnam National University Hwasun Hospital, Jeonnam 519-763, South Korea
c Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, South Korea
*Corresponding authors : In- Kyu Park and Chong-Su Cho
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent MR contrast agents when coated with biocompatible polymers such as hydrophilic synthetic polymers, proteins, polysaccharides, and lipids, which improve their stability and biocompatibility and reduce their aggregation. Various biocompatible materials, coated or conjugated with targeting moieties such as galactose, mannose, folic acid, antibodies and RGD, have been applied to SPION surfaces to provide tissue specificity to hepatocytes, macrophages, and tumor regions in order to reduce non-specific uptake and improve biocompatibility. This review discusses the recent progress in the development of biocompatible and hydrophilic polymers for improving stability of SPIONs and describes the carbohydrates based biocompatible materials that are providing SPIONs with cell/tissue specificity as ligands.
Keywords : Surface modification; iron oxide nanoparticles; biocompatible polymer; tissue imaging; targeting
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