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Abstract
Dr. Jae-Hyun Lee1,‡, Dr. Kuan-Ju Chen2,‡, Seung-Hyun Noh1, Dr. Mitch Andre Garcia2,‡, Prof. Hao Wang2,3, Prof. Wei-Yu Lin2,4, Heeyeong Jeong1, Brian Junoh Kong2, Prof. David B. Stout2, Prof. Jinwoo Cheon1,*, Prof. Hsian-Rong Tseng2,*
1 Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
2 Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA)
3 National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun Haidian District, Beijing, 100190 (P.R. China)
4 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung, 80708 (Taiwan)
‡ These authors contributed equally to this work.
*To whom correspondence should be addressed.
† This research was supported by the NIH (grant numbers R21GM098982 and R21EB016270; H.R.T.), National Creative Research Initiative (2010-0018286; J.C.), and WCU (R32-10217; J.C.).
On-demand drug release: Magnetothermally responsive drug-encapsulated supramolecular nanoparticles for on-demand drug release in vivo have been developed. The remote application of an alternative magnetic field heats the magnetic particles that effectively trigger the release of the drug. An acute drug concentration can be delivered to the tumor in vivo, resulting in an improved therapeutic outcome.
Keywords: drug delivery; magnetic heat induction; magnetic nanoparticles; molecular imaging; supramolecular chemistry
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